Cancer Cytogenetics: Chromosomal and Molecular Genetic Abberations of Tumor Cells 4th Edition, Heim

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Cancer Cytogenetics: Chromosomal and Molecular Genetic Abberations of Tumor Cells 4th Edition by Sverre Heim and Felix Mitelman presents authoritative coverage of neoplastic processes on the chromosomal degree of genomic organization. Now updated and expanded, this book consists of detailed information on the newest advances within the discipline, incorporating an enormous amount of new cytogenetic in addition to molecular genetic information from the most recent basic and medical investigations.

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Edited by two main authorities, who are actually aided by a panel of international specialists, this book contains coverage of acute and persistent myeloproliferative problems with newest findings on acute and chronic lymphoproliferative disorders. This book is a useful resource for researchers in a wide range of fields, including cytogenetics, medical and molecular genetics, cellular and molecular biology, oncology, and hematology.

In fourth Edition there are New contributors reflecting broader international authorship and even greater expertise.

– Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations

– Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date

– Now produced in full color for enhanced clarity

– Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent

– Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible.

Image of Cancer Cytogenetics: Chromosomal and Molecular Genetic Abberations of Tumor Cells 4rd Edition by Sverre Heim and Felix Mitelman
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Table of Contents

Contributors vii

Preface to the Fourth Edition ix

1 How it all began: cancer cytogenetics before sequencing 1

Felix Mitelman and Sverre Heim

2 Cytogenetic methods 11

David Gisselsson

3 Cytogenetic nomenclature 19

Sverre Heim and Felix Mitelman

4 Nonrandom chromosome abnormalities in cancer: an overview 26

Sverre Heim and Felix Mitelman

5 From chromosomes to genes: searching for pathogenetic fusions in cancer 42

Ioannis Panagopoulos

6 Acute myeloid leukemia 62

Bertil Johansson and Christine J. Harrison

7 Myelodysplastic syndromes 126

Harold J. Olney and Michelle M. Le Beau

8 Chronic myeloid leukemia 153

Thoas Fioretos

9 Chronic myeloproliferative neoplasms 175

Peter Vandenberghe and Lucienne Michaux

10 Acute lymphoblastic leukemia 198

Christine J. Harrison and Bertil Johansson

11 Mature B] and T]cell neoplasms and Hodgkin lymphoma 252

Reiner Siebert and Sietse M. Aukema

12 Tumors of the upper aerodigestive tract 332

Susanne M. Gollin

13 Tumors of the lung 361

Penny Nymark, Eeva Kettunen and Sakari Knuutila

14 Tumors of the digestive tract 373

Georgia Bardi and Sverre Heim

15 Tumors of the urinary tract 401

Paola Dal Cin

16 Tumors of the breast 426

Manuel R. Teixeira, Nikos Pandis and Sverre Heim

17 Tumors of the female genital organs 447

Francesca Micci and Sverre Heim

18 Tumors of the male genital organs 481

Manuel R. Teixeira and Sverre Heim

19 Tumors of endocrine glands 497

Jörn Bullerdiek and David Gisselsson

20 Tumors of the nervous system 515

Petter Brandal and Sverre Heim

21 Tumors of the eye 538

Karen Sisley

22 Tumors of the skin 555

Fredrik Mertens, Felix Mitelman and Sverre Heim

23 Tumors of bone 566

Fredrik Mertens and Nils Mandahl

24 Soft tissue tumors 583

Nils Mandahl and Fredrik Mertens

Index 615

Book Details

Publisher ‏ : ‎ Wiley-Blackwell; 4th edition (August 17, 2015)

Language ‏ : ‎ English

Hardcover ‏ : ‎ 648 pages

ISBN-10 ‏ : ‎ 9781118795538

ISBN-13 ‏ : ‎ 978-1118795538

Item Weight ‏ : ‎ 2.94 pounds

Dimensions ‏ : ‎ 6.8 x 1.2 x 9.9 inches

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